Sphera Funds Management Ltd. Top Holdings and 13F Report (2025) About Sphera Funds Management Ltd.Investment ActivitySphera Funds Management Ltd. has $434.31 million in total holdings as of March 31, 2025.Sphera Funds Management Ltd. owns shares of 113 different stocks, but just 49 companies or ETFs make up 80% of its holdings.Approximately 20.24% of the portfolio was purchased this quarter.About 28.46% of the portfolio was sold this quarter.This quarter, Sphera Funds Management Ltd. has purchased 103 new stocks and bought additional shares in 18 stocks.Sphera Funds Management Ltd. sold shares of 51 stocks and completely divested from 9 stocks this quarter.Largest Holdings Teva Pharmaceutical Industries $24,164,422iShares 20+ Year Treasury Bond ETF $23,221,753Syndax Pharmaceuticals $20,441,921Sanofi $16,888,402Nova $16,718,178 Largest New Holdings this Quarter 464287432 - iShares 20+ Year Treasury Bond ETF $23,221,753 Holding578784100 - MAZE THERAPEUTICS INC $3,914,650 Holding45258J102 - Immunovant $3,326,363 Holding67066G104 - NVIDIA $3,208,590 Holding05370A108 - Avidity Biosciences $3,129,120 Holding Largest Purchases this Quarter iShares 20+ Year Treasury Bond ETF 255,100 shares (about $23.22M)Mineralys Therapeutics 274,854 shares (about $4.36M)Nova 22,551 shares (about $4.16M)MAZE THERAPEUTICS INC 355,554 shares (about $3.91M)Sarepta Therapeutics 59,010 shares (about $3.77M) Largest Sales this Quarter BridgeBio Pharma 538,671 shares (about $18.62M)Microsoft 17,735 shares (about $6.66M)Meta Platforms 11,039 shares (about $6.36M)Check Point Software Technologies 27,301 shares (about $6.22M)Wix.com 30,453 shares (about $4.98M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSphera Funds Management Ltd. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorTEVATeva Pharmaceutical Industries$24,164,422$46,110 ▲0.2%1,572,1815.6%MedicalTLTiShares 20+ Year Treasury Bond ETF$23,221,753$23,221,753 ▲New Holding255,1005.3%ETFSNDXSyndax Pharmaceuticals$20,441,921$3,473,375 ▲20.5%1,663,9744.7%MedicalSNYSanofi$16,888,402$4,436,800 ▼-20.8%304,5153.9%MedicalNVMINova$16,718,178$4,156,826 ▲33.1%90,6973.8%Computer and TechnologyAZNAstraZeneca$12,866,910$3,675,000 ▼-22.2%175,0603.0%MedicalBBIOBridgeBio Pharma$12,673,639$18,621,857 ▼-59.5%366,6082.9%MedicalRAREUltragenyx Pharmaceutical$11,492,511$3,208,532 ▲38.7%317,3852.6%MedicalSRPTSarepta Therapeutics$10,079,156$3,766,018 ▲59.7%157,9312.3%MedicalLLYEli Lilly and Company$9,654,888$1,238,865 ▼-11.4%11,6902.2%MedicalCLDXCelldex Therapeutics$9,217,096$612,127 ▲7.1%507,8292.1%MedicalPRAXIS PRECISION MEDICINES I$9,113,794$2,502,336 ▲37.8%240,6602.1%COM NEWJNJJohnson & Johnson$8,761,493$2,819,280 ▼-24.3%52,8312.0%MedicalNVONovo Nordisk A/S$8,199,475$1,388,800 ▲20.4%118,0801.9%MedicalELDNEledon Pharmaceuticals$7,821,133$828,855 ▼-9.6%2,307,1191.8%MedicalMLYSMineralys Therapeutics$7,392,553$4,364,682 ▲144.2%465,5261.7%MedicalAMZNAmazon.com$6,964,848$4,946,760 ▼-41.5%36,6071.6%Retail/WholesaleABBVAbbVie$6,339,237$838,080 ▼-11.7%30,2561.5%MedicalPHVSPharvaris$6,026,539$67,934 ▼-1.1%383,8561.4%MedicalORAOrmat Technologies$5,944,680$353,850 ▲6.3%84,0001.4%EnergyCYTKCytokinetics$5,825,983$2,333,432 ▼-28.6%144,9611.3%MedicalMETAMeta Platforms$5,741,698$6,362,438 ▼-52.6%9,9621.3%Computer and TechnologyNVSNovartis$5,574,0000.0%50,0001.3%MedicalMRKMerck & Co., Inc.$5,349,6960.0%59,6001.2%MedicalORMAT TECHNOLOGIES INC$5,230,2580.0%5,037,0001.2%DEBT 2.500% 7/1NICENICE$5,134,324$1,417,902 ▼-21.6%33,3031.2%Computer and TechnologyGSKGSK$5,036,2000.0%130,0001.2%MedicalSEDGSolarEdge Technologies$5,003,115$1,064,385 ▼-17.5%309,2161.2%EnergyETNB89bio$4,495,354$449,366 ▲11.1%618,3431.0%MedicalMRUSMerus$4,483,932$1,010,160 ▼-18.4%106,5321.0%MedicalIMTXImmatics$4,154,2110.0%921,1111.0%MedicalAPLSApellis Pharmaceuticals$3,966,037$544,672 ▼-12.1%181,3460.9%MedicalMAZE THERAPEUTICS INC$3,914,650$3,914,650 ▲New Holding355,5540.9%COMTVTXTravere Therapeutics$3,584,000$370,944 ▼-9.4%200,0000.8%MedicalSVRASavara$3,557,098$201,152 ▲6.0%1,284,1510.8%MedicalARWRArrowhead Pharmaceuticals$3,535,987$1,019,200 ▲40.5%277,5500.8%MedicalDYNE THERAPEUTICS INC$3,444,081$972,780 ▲39.4%329,2620.8%COMANNXAnnexon$3,405,267$1,006,202 ▲41.9%1,764,3870.8%MedicalJANXJanux Therapeutics$3,397,680$1,552,689 ▲84.2%125,8400.8%MedicalCYBIN INC$3,342,588$69,036 ▼-2.0%527,2220.8%COM NEWIMVTImmunovant$3,326,363$3,326,363 ▲New Holding194,6380.8%MedicalNVDANVIDIA$3,208,590$3,208,590 ▲New Holding29,6050.7%Computer and TechnologyRZLTRezolute$3,136,196$244,899 ▼-7.2%1,081,4470.7%MedicalRNAAvidity Biosciences$3,129,120$3,129,120 ▲New Holding106,0000.7%MedicalAMGNAmgen$3,115,500$3,115,500 ▲New Holding10,0000.7%MedicalBIIBBiogen$3,111,4680.0%22,7380.7%MedicalALPHA COGNITION INC$3,020,780$116,420 ▼-3.7%596,9920.7%COM NEWVIGLVigil Neuroscience$2,855,884$181,560 ▲6.8%1,604,4290.7%MedicalNTLAIntellia Therapeutics$2,709,479$604,350 ▼-18.2%381,0800.6%MedicalDAWNDay One Biopharmaceuticals$2,656,4470.0%334,9870.6%MedicalAMATApplied Materials$2,612,160$2,612,160 ▲New Holding18,0000.6%Computer and TechnologySRRKScholar Rock$2,513,905$385,800 ▼-13.3%78,1930.6%MedicalCRMSalesforce$2,442,076$2,442,076 ▲New Holding9,1000.6%Computer and TechnologyBHVNBiohaven$2,398,807$1,363,308 ▼-36.2%99,7840.6%MedicalENGENE HOLDINGS INC$2,367,075$141,725 ▼-5.6%528,3650.5%COMSKYE BIOSCIENCE INC$2,347,401$140,357 ▼-5.6%1,476,3530.5%COM NEWWDAYWorkday$2,335,3000.0%10,0000.5%Computer and TechnologySWTXSpringWorks Therapeutics$2,295,157$2,117,843 ▼-48.0%52,0090.5%MedicalPFEPfizer$2,280,6000.0%90,0000.5%MedicalKURAKura Oncology$2,267,245$1,759,329 ▼-43.7%343,5220.5%MedicalELVNEnliven Therapeutics$2,199,102$2,199,102 ▲New Holding111,7430.5%MedicalTSEMTower Semiconductor$2,194,837$3,730,035 ▼-63.0%61,5490.5%Computer and TechnologyUBERUber Technologies$2,185,8000.0%30,0000.5%Computer and TechnologyGOOGAlphabet$2,109,105$4,686,900 ▼-69.0%13,5000.5%Computer and TechnologyVKTXViking Therapeutics$2,010,971$483,000 ▼-19.4%83,2700.5%MedicalCOGTCogent Biosciences$2,006,794$2,006,794 ▲New Holding335,0240.5%MedicalVTGNVistagen Therapeutics$1,976,375$45,000 ▼-2.2%790,5500.5%MedicalAVGOBroadcom$1,958,094$868,125 ▼-30.7%11,6950.5%Computer and TechnologyIONSIonis Pharmaceuticals$1,925,4800.0%63,8210.4%MedicalNKENIKE$1,907,574$1,907,574 ▲New Holding30,0500.4%Consumer DiscretionaryCHKPCheck Point Software Technologies$1,899,485$6,222,443 ▼-76.6%8,3340.4%Computer and TechnologyRCKTRocket Pharmaceuticals$1,812,8530.0%271,7920.4%MedicalMSFTMicrosoft$1,723,791$6,657,542 ▼-79.4%4,5920.4%Computer and TechnologyNTRNutrien$1,534,505$1,241,750 ▼-44.7%30,8940.4%Basic MaterialsGPCRStructure Therapeutics$1,454,040$1,454,040 ▲New Holding84,0000.3%MedicalWIXWix.com$1,437,744$4,975,411 ▼-77.6%8,8000.3%Computer and TechnologyFROGJFrog$1,371,872$4,720,320 ▼-77.5%42,8710.3%Computer and TechnologyCAMTCamtek$1,353,532$773,975 ▼-36.4%23,0860.3%Computer and TechnologyPMNProMIS Neurosciences$1,341,8260.0%1,929,2970.3%MedicalSHLTSHL Telemedicine$1,311,0810.0%632,4560.3%MedicalORICORIC Pharmaceuticals$1,310,374$214,155 ▼-14.0%234,8340.3%MedicalCEVACEVA$1,252,841$1,252,841 ▲New Holding48,9200.3%Computer and TechnologyBMYBristol-Myers Squibb$1,219,8000.0%20,0000.3%MedicalVTYXVentyx Biosciences$1,164,6610.0%1,012,7490.3%MedicalNNDMNano Dimension$1,140,854$1,140,854 ▲New Holding717,5180.3%Computer and TechnologyINZYInozyme Pharma$1,083,9370.0%1,191,1400.2%MedicalOUTLOOK THERAPEUTICS INC$1,045,713$1,045,713 ▲New Holding857,1420.2%COMATXSAstria Therapeutics$1,013,532$267,000 ▲35.8%189,8000.2%MedicalCMMBChemomab Therapeutics$981,467$342,420 ▼-25.9%900,4280.2%MedicalPERSPECTIVE THERAPEUTICS INC$980,3260.0%460,2470.2%COM NEWMRVLMarvell Technology$927,860$3,912,220 ▼-80.8%15,0700.2%Computer and TechnologyARVNArvinas$877,500$877,500 ▲New Holding125,0000.2%MedicalXENEXenon Pharmaceuticals$875,554$872,300 ▼-49.9%26,0970.2%MedicalPERIPerion Network$835,2620.0%102,6120.2%Computer and TechnologyRGLSRegulus Therapeutics$792,479$792,479 ▲New Holding452,8450.2%MedicalLRMRLarimar Therapeutics$787,554$191,995 ▼-19.6%366,3040.2%MedicalCRVSCorvus Pharmaceuticals$654,632$936,930 ▼-58.9%205,8590.2%MedicalHOWLWerewolf Therapeutics$609,3850.0%626,8100.1%MedicalVIRVir Biotechnology$588,740$3,181,509 ▼-84.4%90,8550.1%MedicalAPREAprea Therapeutics$550,8000.0%270,0000.1%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
